FIELD: medicine.
SUBSTANCE: invention relates to microbiology and immunology and can be used for immunogenicity enhancement of vaccine strain of plague microbe for use in making medical immunobiological preparations. Method for increasing immunogenicity of a vaccine strain of a plague microbe involves growing a lyophilised culture of the Y. pestis EV NIIEG 1 vaccine strain in vitro on LB agar culture medium, Miller pH 7.2 ± 0.1 with addition of polyoxydonium immunoadjuvant in final concentration of 60 mcg/ml at temperature 28 °C for 48 hours.
EFFECT: invention simplifies the method of producing a vaccine strain of a plague microbe with high immunogenicity.
1 cl, 3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR INCREASING IMMUNOGENIC AND PROTECTIVE ACTIVITY OF VACCINE STRAIN OF PLAGUE MICROBE | 2023 |
|
RU2815337C1 |
| METHOD OF ISOLATING PLAGUE MICROBE BY BACTERIOLOGICAL METHOD FROM INVESTIGATED MATERIAL (VERSIONS) | 2007 |
|
RU2353654C1 |
| BACTERIAL STRAINS KIT USED FOR TRAINING ON MICROBIOLOGY AND PLAGUE LABORATORY DIAGNOSTICS METHODS | 2016 |
|
RU2642322C1 |
| METHOD OF DETECTING A PLAGUE MICROBE AND A SET OF REAGENTS FOR ITS IMPLEMENTATION | 2022 |
|
RU2796820C1 |
| LIQUID NUTRITIONAL MEDIUM FOR CULTIVATION AND DISCHARGE OF BIOMASS OF VACCINE STRAIN OF PLAGUE MICROBE (YERSINIA PESTIS EV) | 2020 |
|
RU2745504C1 |
| DENSE NUTRIENT MEDIUM FOR CULTIVATION AND COLLECTION OF BIOMASS OF PLAGUE MICROBE OF YPESTIS EV VACCINE STRAIN | 2016 |
|
RU2626568C1 |
| METHOD FOR PREPARING IMMUNOGENIC PREPARATION FROM YERSINIA PESTIS EV | 2003 |
|
RU2248217C2 |
| RECOMBINANT STRAIN OF SALMONELLA MINNESOTA - A PRODUCER OF PLAGUE MICROBE CAPSULE ANTIGENE | 1992 |
|
RU2046145C1 |
| DENSE NUTRIENT MEDIUM FOR CULTIVATION AND COLLECTION OF BIOMASS OF VACCINE STRAIN OF PLAGUE MICROBE YERSINIA PESTIS EV | 2018 |
|
RU2702174C1 |
| STRAIN OF BACTERIA JERSINIA PESTIS, USED FOR CONTROL SYNTHESIS OF L-ARGININE AT THE STAGE OF L-ARGININOSUCCINATE FORMATION | 0 |
|
SU1661207A1 |
