FIELD: immunology.
SUBSTANCE: disclosed is an isolated nucleic acid molecule encoding a multispecific activated antibody, wherein the antibody is linked to cleaved peptide groups, which are a substrate for proteases, and masking groups. What is also presented is an expression vector, methods for producing a multispecific antibody and using the antibody to relieve a symptom of the clinical disease of the patient.
EFFECT: present group of inventions enables to obtain and use multispecific antibodies having high selectivity.
19 cl, 11 tbl, 16 ex, 23 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| MULTISPECIFIC ANTIBODIES, MULTISPECIFIC ACTIVATED ANTIBODIES AND METHODS OF USE THEREOF | 2014 |
|
RU2815683C2 |
| ANTIBODIES BINDING TO CD3 | 2019 |
|
RU2810924C2 |
| ANTIBODIES BINDING TO CD3 | 2019 |
|
RU2832669C2 |
| OBTAINING MULTISPECIFIC MIXTURES OF ANTIBODIES AND METHODS OF USE THEREOF | 2018 |
|
RU2815826C2 |
| POLYPEPTIDE LINKER FOR PRODUCTION OF MULTI-SPECIFIC ANTIBODIES | 2018 |
|
RU2776302C2 |
| MULTISPECIFIC ANTIBODY WITH BINDING SPECIFICITY OF HUMAN IL-13 AND IL-17 | 2020 |
|
RU2827946C1 |
| ANTIBODIES TO CHELATED RADIONUCLIDES | 2019 |
|
RU2833233C2 |
| MULTI-SPECIFIC ANTIBODIES AND METHODS OF THEIR PRODUCTION AND USE | 2018 |
|
RU2811477C2 |
| ANTIBODY TO CD3 AND ITS PHARMACEUTICAL USE | 2019 |
|
RU2802272C2 |
| ENGINEERED MULTI-SPECIFIC ANTIBODIES AND OTHER MULTIMERIC PROTEINS WITH ASYMMETRIC MUTATIONS IN THE CH2-CH3 REGION | 2018 |
|
RU2804031C2 |
