FIELD: immunology.
SUBSTANCE: disclosed is an isolated nucleic acid molecule encoding a multispecific activated antibody, wherein the antibody is linked to cleaved peptide groups, which are a substrate for proteases, and masking groups. What is also presented is an expression vector, methods for producing a multispecific antibody and using the antibody to relieve a symptom of the clinical disease of the patient.
EFFECT: present group of inventions enables to obtain and use multispecific antibodies having high selectivity.
19 cl, 11 tbl, 16 ex, 23 dwg
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