FIELD: chemistry.
SUBSTANCE: invention relates to a continuous method of producing Etravirine (I) in a flow type reactor which includes reacting 4-[(4-amino-5-bromo-6-chlorpyrimidin-2-yl)amino]benzonitrile, dissolved in an aprotic solvent, with alkali metal salt of 4-hydroxy-3,5-dimethylbenzonitrile at reaction temperature of 120 to 180 °C during reaction in range from 1 to 120 min.
EFFECT: novel method of producing high-quality Etravirine with high output in a short reaction time.
5 cl, 1 dwg, 9 ex
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