FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention refers to compounds of formula (I) and use thereof for treating diseases and conditions mediated by GPR119. In general formula (I), each of X1, X2, X3, X4 and X5 independently represents N, S or CH; and X4 and X5 are combined with formation of five-member ring containing atom N, R1 and R2 are H, values A and B are given in the claim.
(I)
EFFECT: disclosed are heterocyclic substances—GPR119 agonists.
28 cl, 2 tbl, 40 ex
Title | Year | Author | Number |
---|---|---|---|
THIAZOLOPYRIDINE DERIVATIVES AS GPR119 AGONISTS | 2017 |
|
RU2749111C2 |
PIPERIDINE DERIVATIVES | 2011 |
|
RU2554353C2 |
PYRIDINES SUBSTITUTED WITH HETEROARYL AND APPLICATION METHODS | 2017 |
|
RU2756743C2 |
HETEROARYL COMPOUNDS AS TKB INHIBITORS AND USE THEREOF | 2015 |
|
RU2742122C2 |
DERIVATIVE OF 2-SUBSTITUTED SACCHARIN AND PHARMACEUTICAL COMPOSITION SHOWING INHIBITORY ACTIVITY WITH RESPECT TO ELASTASE | 1992 |
|
RU2101281C1 |
MINERALOCORTICOID RECEPTOR ANTAGONISTS | 2012 |
|
RU2598842C2 |
5-OXA-2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | 2020 |
|
RU2820477C1 |
METHOD OF PREPARING 3-HALOGENALKYL-1H- PYRAZOLES | 1996 |
|
RU2169143C2 |
MACROCYCLIC TYROSINE KINASE INHIBITOR AND ITS USE | 2019 |
|
RU2798231C2 |
SUBSTITUTED IMIDAZOPYRIDINES AS HDM2 INHIBITORS | 2013 |
|
RU2690663C2 |
Authors
Dates
2020-10-19—Published
2017-04-05—Filed