METHOD FOR SYNTHESIS OF FLUOROCLOZAPINE AND DERIVATIVES THEREOF Russian patent published in 2015 - IPC C07D403/04 C07D495/04 

Abstract RU 2557241 C1

FIELD: chemistry.

SUBSTANCE: method includes reacting 2,4-difluoro-5-nitro-1-chlorobenzene (2) with a compound of formula (3) to obtain a compound of formula (4) , reducing the compound of formula (4) with sodium dithionite in a suitable solvent to obtain a compound of formula (5) , ring closure of the compound of formula (5) to form a compound of formula (6) , crystallising a compound of formula (7) from the compound of formula (6), reacting said compound of formula (7) with an amino derivative of a compound of formula (9)

EFFECT: high degree of purity.

10 cl, 4 dwg, 4 ex

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RU 2 557 241 C1

Authors

Zapol'Skij Maksim Ehduardovich

Morozova Margarita Alekseevna

Beniashvili Allan Gerovich

Dates

2015-07-20Published

2014-07-31Filed