FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a continuous method of producing tadalafil in a flow type reactor of methyl (1R,3R)-1-(1,3-benzodioxol-5-yl)-2,3,4,9-tetrahydro-2-chloroacetyl-1H-pyrido[3,4-b]indole-3-carboxylate and methylamine in an aprotic solvent during the reaction in range of 1 to 60 minutes.
EFFECT: high quality of the product with high output at low temperature in a short time.
6 cl, 2 dwg, 12 ex
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