NEW ISOINDOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION INCLUDING THEREOF AND USE THEREOF Russian patent published in 2020 - IPC C07D209/48 C07D209/49 A61K31/4035 A61K31/4439 A61P37/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula I

or a pharmaceutically acceptable salt thereof, stereoisomer or isotopic compound, wherein a carbon atom marked with * represents a center of asymmetry; R1 and R2 independently represent H, R⁶-S(O)₂-, or R⁶-C(O)-; R⁶ is unsubstituted (C₃)cycloalkyl; or (C₁-C₆)alkyl, which is optionally substituted with one or more groups selected from D, halogen, hydroxyl, amino, (C₁-C₆) alkylamino, (C₁-C₆)alkoxy and benzyloxy; X¹, X², X³, X⁴, X⁵ and X⁶ independently represent CH, CR⁷ or N; R⁷ is halogen or cyano; R³ and R⁴ independently represent H, substituted or unsubstituted (C₁-C₆) alkyl; R⁵ is unsubstituted (C₁-C₆) alkyl; R¹⁰, R¹¹ and R¹² independently represent H or D; substituent in the substituted (C₁-C₆) alkyl is one or more selected from the group consisting of: D, halogen, hydroxyl, amino, (C₁-C₆) alkylamino, (C₁-C₆) alkoxy and benzyloxy; when there are several substitutes, these substitutes are identical or different from each other; provided that: one of X¹, X², X³, X⁴, X⁵ and X⁶ is N, which can regulate generation and/or activity of PDE4 and/or TNF-α.

EFFECT: invention discloses a novel isoindoline derivative which includes a pharmaceutical composition and use thereof.

20 cl, 47 ex, 2 tbl