FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to a compound of formula (II), or an isomer thereof, or a pharmaceutically acceptable salt thereof:
.
In formula II: R1 denotes H or -NHR3; R3 represents H, C1-6 alkyl or 4–6 membered heterocyclyl, wherein alkyl and heterocyclyl is optionally substituted with halo, -OR5, C1-6 alkyl, C3-6 cycloalkyl, or 4–6 membered heterocyclyl; X is absent or represents C1-6 alkylene; Y is absent or is C3-6 cycloalkylene or 4–6-member heterocyclylene; Z is cyano,
bond a is a double bond or triple bond; in the event that said bond is a double bond, each Ra, Rb and Rc are independently H, halogen or C1-6 alkyl, wherein alkyl is optionally substituted with -OC1-2 alkyl or -N(C1-2 alkyl)2; in the event that said bond is a triple bond, Ra and Rc are absent and Rb is H or C1-6 alkyl; Ga, Gb, Gc and Gd, each independently selected from a group consisting of H, halogen, -OR5 and -C(O)NR6R7; R4, R5, R6 and R7, each independently represent H or C1-6 alkyl, wherein n in formula II is optionally substituted by 2N. Also presented is a pharmaceutical composition and a method of treating.
EFFECT: technical result: novel organic compounds acting as fibroblast growth factor receptor (FGFR) inhibitor.
11 cl, 2 tbl, 34 ex
Title | Year | Author | Number |
---|---|---|---|
3,5-DISUBSTITUTED ALKYNYLBENZENE COMPOUND AND SALT THEREOF | 2013 |
|
RU2576384C1 |
SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | 2011 |
|
RU2652638C2 |
NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF | 2014 |
|
RU2666349C2 |
PIPERIDINE DERIVATIVE, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | 2016 |
|
RU2730508C2 |
SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK, THEIR PREPARATION AND USE IN TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASES | 2014 |
|
RU2677884C2 |
ANTITUMOR DRUG FOR INTERMITTENT ADMINISTRATION OF FGFR INHIBITOR | 2014 |
|
RU2664118C2 |
NOVEL COMPOUND OF 2,3,5-SUBSTITUTED THIOPHENE AS A PROTEIN KINASE INHIBITOR | 2017 |
|
RU2724957C2 |
INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR | 2013 |
|
RU2679130C2 |
PYRROLIDINE AND PIPERIDINE COMPOUNDS | 2020 |
|
RU2803455C1 |
COMPOUNDS OF 1-CYANO-PYRROLIDINES AS USP30 INHIBITORS | 2016 |
|
RU2717238C2 |
Authors
Dates
2020-08-04—Published
2017-01-25—Filed