NEW DERIVATIVES OF CYP-EICOSANOIDS Russian patent published in 2020 - IPC C07C309/21 C07C311/51 C07C323/41 C07D277/82 C07D291/04 C07F9/30 C07F9/32 A61K31/165 A61K31/185 A61K31/41 A61K31/661 A61P9/06 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of general formula P-E-I (I) or a pharmaceutically acceptable salt thereof, wherein P is a group represented by general formula -(CH₂)_n-B-(CH₂)_k-X (II), where B is a carbon-carbon bond; n is 0 or is integer from 3 to 8; and k is 0 or 1; provided that, if n is equal to 0, k is equal to 1; X is a group whose structure is given in the claim, wherein R¹ represents a hydroxyl group; R² is -NHR³; where R³ is (SO₂R³⁰); R³⁰ represents C₆ aryl group; R⁴ denotes phenyl substituted with -OH; h equals 0; each of R⁶ and R⁷ independently represents a hydroxyl group; -O(C₁-C₆)alkyl group or -O(C₁-C₆)alkyldiyl-O(C=O)(C₁-C₆) alkyl group; each of R⁸ and R^8' independently represents a hydrogen atom; -C(=O)C₁-C₆alkyl; R⁹ is C₁-C₆ alkyl or C₆aryl; g is equal to 2; X¹ is NH; E represents a group represented by general formula (III) or (IV), where each of R¹² and R¹³ independently represents a hydrogen atom; I is -(CH₂)_m-Y, where Y is a group (a), where each of R⁴⁰ and R⁴¹ is a hydrogen atom; R⁴² is a methyl group; m is equal to 3 or 4, provided that when E is a group according to general formula (IV), m is 3; and where L and T both represent a carbon atom.

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EFFECT: compounds of formula (I) are intended for treating or preventing ventricular arrhythmia or atrial fibrillation; compounds are also intended for treating a condition or disease, on which the positive effect of introduction of derivatives of polyunsaturated fatty acids (PUFA) omega-3 (n-3), wherein administering to a patient in need thereof at least one compound of formula (I) in an amount effective for treating a condition or disease in which introduction of derivatives of PUFA n-3 has a positive effect.

13 cl, 1 dwg, 10 ex