AROMATASE INHIBITORS Russian patent published in 2016 - IPC C07D249/08 C07D401/12 C07D403/12 C07D405/12 C07D409/12 A61K31/4196 A61K31/496 A61K31/5355 A61K31/55 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compounds of formula V or Va and their pharmaceutically acceptable salts. In formula V or Va D is selected from the group, including linear hydrocarbon groups, which contain carbon chain, containing from 1 to 2 carbon atoms; R₄ stands for -CN; R₂ and R₅ stand for H; each of R₃ and R₆ is independently selected from the group, including -H, halogen, -NR₁₂R₁₃ and -(CH₂)_0-1R₁₄; R₁₂ and R₁₃ together with atoms, which they are bound to, can form monocyclic ring, containing from 5 to 8 ring elements; R₁₄ stands for each of R₁₇-R₂₁ is independently selected from the group, including -H, halogen, -O-(C₁-C₆)halogenalkyl, -CN, -OH, -OBn, -OSO₂NR₁₅R₁₆, -O-(C₁-C₆)alkyl; R₁₅ and R₁₆ are selected from H; each of R₇-R₁₁ is independently selected from the group, including -H, halogen, -OH, -OBn, -OSO₂NR₁₅R₁₆; R₁₅ and R₁₆ are independently selected from the group, including H Invention also relates to pharmaceutical composition.

EFFECT: invention compounds possess inhibiting activity with respect to STS and/or aromatase.

25 cl, 2 dwg