FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula
,
where R1 is -(CH2)n-phenyl, wherein the phenyl group is optionally substituted with one to five substitutes selected from halogen, OH, (C1-C6)-alkyl; R2 is -(CH2)n-phenyl, where phenyl is substituted with one to five substitutes selected from halogen; R3 is phenyl, wherein phenyl is optionally substituted with one to five substitutes selected from halogen, OH, (C1-C6)-alkyl; X is -COOR", wherein R" is H or (C1-C4)-alkyl; R4 and R5 independently of each other or simultaneously represent H or CF3, wherein one of R4 or R5 is H or together R4 and R5 are -C(=O); R is H, OH; n is independently 0, 1 and m is 1 or 2, which is STAT5 inhibitors.
EFFECT: disclosed are sulphonamide compounds and use thereof as STAT5 inhibitors.
26 cl, 19 dwg, 1 tbl, 9 ex
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