FIELD: immunology.
SUBSTANCE: disclosed is a method of producing a polypeptide which specifically binds to staphylococcus protein A and does not bind to human FcRn containing two polypeptides, wherein the first and second polypeptides contain mutations H310A, H433A and Y436A.
EFFECT: disclosed invention can find further application in producing polypeptides with reduced clearance and longer half-life.
8 cl, 45 tbl, 20 dwg, 8 ex
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