VARIANTS OF FC-REGION WITH MODIFIED ABILITY TO BIND TO FCRN AND WITH PRESERVED ABILITY TO BIND WITH PROTEIN A Russian patent published in 2020 - IPC C12P21/08 C07K16/22 A61K39/00

Abstract RU 2727639 C2

FIELD: immunology.

SUBSTANCE: there are presented methods for producing a polypeptide which specifically binds to staphylococcus protein A and does not bind to human FcRn containing four polypeptides.

EFFECT: disclosed invention can find further application in producing polypeptides with reduced clearance and longer half-life.

11 cl, 45 tbl, 20 dwg, 8 ex

Similar patents RU2727639C2

Title	Year	Author	Number
VERSIONS OF THE FC-DOMAIN WITH MODIFIED ABILITIES TO BIND TO FCRN	2015	Shlotauer Tilman	RU2730592C2
ANTIBODIES BINDING TO CD3	2019	Freimoser-Grundschober Anne Hofer Thomas Hosse Ralf Moessner Ekkehard Nicolini Valeria G. Umana Pablo Waldhauer Inja Richter Wolfgang Knaupp Alexander Trochanowska Halina	RU2810924C2
PSEUDO-FAB BASED MULTISPECIFIC BINDING PROTEINS	2019	Weil, Sandra Rao, Ercole Leuschner, Wulf-Dirk Langer, Thomas Hoelper, Soraya Engel, Karl-Christian Beil, Christian Hessler, Gerhard Lange, Christian Lemoine, Cendrine Oezguer Bruederle, Sevim Spindler, Nadja	RU2820254C2
ANTIBODIES BINDING TO CD3	2019	Frajmozer-Grundshober Anne Khofer Tomas Khosse Ralf Messner Ekkekhard Nikolini Valeriya G. Umanya Pablo Valdkhauer Inya Rikhter Volfgang Knaupp Aleksander Trokhanovska Khalina	RU2832669C2
CD3-BINDING DOMAIN	2015	Zhukovskij Evgenij Litl Melvin Knakmuss Shtefan Rojsh Uve Ellvanger Kristina Futsek Ivitsa Vajkhel Mikhael Eser Markus Makalis-Eser Fionnuala	RU2742691C2
ANTIBODIES BINDING TO GPRC5D	2020	Bujotzek Alexander Christopeit Tony Fauti Tanja Fertig Georg Haegel Helene Cecile Klein Christian Kraft Thomas Lorenz Stefan Mayoux Maud Lea Schneider Anneliese	RU2841523C2
MULTISPECIFIC BINDING PROTEINS WITH MUTANT DOMAINS FAB	2019	Amaral, Marta Beil, Christian Focken, Ingo Hessler, Gerhard Hoelper, Soraya Jung, Jennifer Lange, Christian Leuschner, Wulf-Dirk Rao, Ercole Tiwari, Garima Weil, Sandra	RU2827657C2
ANTIBODY CAPABLE OF BINDING TO THYMIC STROMAL LYMPHOPOIETIN, AND USE THEREOF	2020	Shi Tszinpin In Khua Li Tintin Van Ifan Yan Gujmej Ge Khu Tao Vejkan	RU2825304C2
POLYVALENT AND POLYSPECIFIC GITR-BINDING FUSED PROTEINS	2016	Timmer Dzhon K. Dzhons Kajl S. Razai Amir S. Khussejn Abrakhim Villis Ketlin M. Devero Kuinn Ekelman Brendan P.	RU2753439C2
PROTEINS BINDING NKG2D, CD16 AND TUMOUR-ASSOCIATED ANTIGEN	2018	Chang, Gregory, P. Cheung, Ann, F. Haney, William Lunde, Bradley, M. Prinz, Bianka Grinberg, Asya	RU2816716C2

RU 2 727 639 C2

Authors

Shkolaut Aleksander

Shlotauer Tilman

Dates

2020-07-22—Published

2015-01-12—Filed