FIELD: immunology.
SUBSTANCE: there are presented methods for producing a polypeptide which specifically binds to staphylococcus protein A and does not bind to human FcRn containing four polypeptides.
EFFECT: disclosed invention can find further application in producing polypeptides with reduced clearance and longer half-life.
11 cl, 45 tbl, 20 dwg, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| VERSIONS OF THE FC-DOMAIN WITH MODIFIED ABILITIES TO BIND TO FCRN | 2015 |
|
RU2730592C2 |
| PSEUDO-FAB BASED MULTISPECIFIC BINDING PROTEINS | 2019 |
|
RU2820254C2 |
| ANTIBODIES BINDING TO CD3 | 2019 |
|
RU2810924C2 |
| CD3-BINDING DOMAIN | 2015 |
|
RU2742691C2 |
| POLYVALENT AND POLYSPECIFIC GITR-BINDING FUSED PROTEINS | 2016 |
|
RU2753439C2 |
| PROTEINS BINDING NKG2D, CD16 AND TUMOUR-ASSOCIATED ANTIGEN | 2018 |
|
RU2816716C2 |
| BINDING MOLECULES, BINDING PD-L1 AND LAG-3 | 2017 |
|
RU2784388C2 |
| PROTEIN BINDING WITH NKG2D, CD16 AND WITH TUMOR-SPECIFIC ANTIGEN | 2018 |
|
RU2788531C2 |
| ANTIBODIES BINDING TO GPRC5D | 2019 |
|
RU2797268C2 |
| EMBODIMENTS OF Fc-REGION WITH MODIFIED BINDING PROPERTIES OF FcRn AND PROTEIN A | 2015 |
|
RU2713131C1 |
