INHALER FOR DRY POWDER AND SYSTEM FOR DRUG DELIVERY Russian patent published in 2020 - IPC A61M15/00 

FIELD: medical equipment.

SUBSTANCE: group of inventions relates to two versions of a cartridge for dry powdered medicament for an inhaler and four versions of an inhalation system for delivery of dry powdered medicament into respiratory tract. In the first version, the cartridge comprises a chamber configured to hold the drug. Cartridge has an inlet to provide a flow inlet into the chamber and a dispensing opening to allow flow of the flow from the chamber. One inlet is configured to direct the flow entering the inlet to said dispensing opening inside the chamber in response to the pressure difference. Inlet hole is located near dispensing opening along horizontal axis. In the second version of the cartridge holes are made with the least size of less than 3 mm to prevent release of larger aggregates of powder. In the first version, the system comprises a dry powder inhaler provided with two inlet openings. First inlet is in communication with the first channel for air flow, and the second inlet is in communication with the second channel for air flow. First and second air flow channels converge perpendicularly during inhalation action. Inhalation system has total flow resistance in the dosage configuration, which is within range of 0.065 to 0.200 (√kPa)/liter per minute. In the second version, the system comprises an inhaler comprising a container installation area configured to receive the container and a mouthpiece having two inlet openings and one outlet. First inlet is in fluid communication with container mounting region, and the second inlet is in fluid communication with the outlet through the flow passage, bypassing the container mounting area. First inlet hole and the second inlet hole include flows converging perpendicularly. Flow passage, bypassing the area of the container installation, delivers 30–90 % of the total flow passing through the inhaler during inhalation. In the third version, the system comprises an inhaler for dry powder containing a container area and a container. Dry powder inhaler and container are connected and provided to provide flow passes in dispensing configuration and structural areas, which provide mechanisms for inhalation powder deagglomeration when in use. One of the mechanisms for deagglomeration is a hole in the area of the container, which limits the size of passing agglomerates and has the smallest size less than 3 mm. Container comprises top part. Upper part and container are made with possibility of translational movement relative to each other. In the fourth version, the system comprises an inhaler for dry powder containing a mouthpiece and a container. Dry powder inhaler and said container are connected and provided to provide flow passes in dispensing configuration and structural areas, which provide mechanisms for inhalation powder deagglomeration when in use. One of the deagglomeration mechanisms is an air passage made in the mouthpiece, which directs the flow to the outlet, in a fluid communication with the container. Container comprises top part. Upper part and container are made with possibility of translational movement relative to each other.

EFFECT: technical result is ease of use without discomfort and with dismountable configurations of inhaler, which would allow better matching with patient parameters.

41 cl, 81 dwg