DIKETOPIPERAZIN MICROPARTICLES WITH PARTICULAR AMOUNT OF ISOMERS Russian patent published in 2013 - IPC A61K47/22 A61K9/16 A61K38/02 A61K38/22 A61K38/28 A61K38/29 A61K38/26 C07D241/08 A61P3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: there are described fumaryl diketopiperazin (FDKP) formulations and microparticles with the particular amount of trans-isomer making approximately 45% to approximately 65%. The FDKP microparticles can contain a drug such as endocrine hormone including a peptide, including insulin, glucagon, parathyroid hormone, and can be used to prepare a powder for pulmonary drug delivery.

EFFECT: fumaryl diketopiperazin (FDKP) microparticles with the above amount of trans-isomer show the improved aerodynamic properties.

27 cl, 6 dwg, 6 tbl, 3 ex