HUMANISED ANTIBODY OR ITS ANTIGEN-BINDING FRAGMENT (FAB) AGAINST FIRST AND/OR SECOND TYPE SHIGA LIKE TOXINS (EMBODIMENTS), COMPOSITION FOR TREATING ENTEROHAEMORRHAGIC ESCHERICHIA COLI TOXIC CONDITIONS, CONTAINING SAID ANTIBODIES AND/OR FAB Russian patent published in 2020 - IPC C07K16/12 A61K39/395 A61P31/04 

Abstract RU 2732155 C1

FIELD: immunology.

SUBSTANCE: present invention relates to immunology. There are presented humanised antibodies or their antigen-binding fragments selectively binding with shiga-like toxins of the first and/or second type and neutralizing them. What is also considered is a composition containing a mixture of the above antibodies.

EFFECT: present invention can find further application in therapy of toxic conditions caused by enterohaemorrhagic Escherichia coli.

6 cl, 1 tbl, 4 ex, 4 dwg

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RU 2 732 155 C1

Authors

Solopova Olga Nikolaevna

Bokov Maksim Nikolaevich

Varlamov Nikolaj Evgenevich

Pozdnyakova Lyubov Petrovna

Sveshnikov Petr Georgievich

Shemchukova Olga Borisovna

Aliev Tejmur Kantamirovich

Balabashin Dmitrij Sergeevich

Ilina Ekaterina Nikolaevna

Larina Mariya Viktorovna

Dates

2020-09-11Published

2019-09-24Filed