FIELD: biotechnology; immunology.
SUBSTANCE: disclosed is a humanised antibody and its antigen-binding fragment specifically binding to folic acid receptor 1 (FOLR1) and characterized by amino acid sequences of sections, determining complementarity with antigen (CDR). Also disclosed is a method of producing a humanised antibody according to the invention; immunoconjugates with a cytotoxic agent; pharmaceutical compositions; diagnostic composition; sets; methods for inhibiting tumor growth and a method of treating cancer. Disclosed are isolated polynucleotides encoding the antibody variable domains under the invention; containing vectors and host cells.
EFFECT: antibody according to the invention can find further application in therapy of diseases characterized by high expression of FOLR1.
55 cl, 4 tbl, 19 ex, 19 dwg
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|
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