PHENOTHIAZINE DERIVATIVES AND METHODS FOR USE THEREOF Russian patent published in 2020 - IPC A61K31/5415 C07D279/28

Abstract RU 2732417 C1

FIELD: chemistry.

SUBSTANCE: invention relates to phenothiazine derivatives of formula (Ia)

, where:

Oligo is an oligomer or a co-oligomer selected from a group consisting of -[CH₂CH(OR¹)CH₂O]_m-R², -[CH₂CH(OR¹)CH₂O]_m-[CH₂CH₂O]_n-R² and -[CH₂CH₂O]_n-[CH₂CH(OR¹)CH₂O]_m-R²; R is halogen or C₁-C₄ alkyl substituted with one or more halogens; each of R¹, R² and R³ independently represents H or C₁-C₄ alkyl; X is C(O), C(O)O or C(O)CH₂O; m is an integer ranging from 2 to 16, and n is an integer within range of 3 to 16, pharmaceutical compositions based thereon, methods of treating cancer.

EFFECT: there are prepared phenothiazine derivatives possessing antitussive activity and applicable for cancer treatment, where cancer is non-small-cell lung cancer (NSCLC), colon cancer, breast cancer or pancreatic cancer.

61 cl, 5 tbl, 6 ex

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RU 2 732 417 C1

Authors

Cheng Haiyung

Lin Chi-Feng

Shih Jhen-Hua

Wu Alexander C. H.

Dates

2020-09-16—Published

2017-09-14—Filed