FIELD: chemistry.
SUBSTANCE: invention relates to derivatives of 1,2,3,4-tetrahydropyrido[4,3-b]indole-containing phenothiazines of general formula 1 
as inhibitors of cholinestrerases and blockers of serotonin receptors 5-HT6, a pharmaceutical preparation on their base, in particular for treatment of neurodegenerative diseases. In general formula 1, in which R1=H, (C1-C6) alkyl; R2, R3, R4, R5=H, F, Cl, Br, (C1-C6) alkyl, (C1-C6) alkoxy, R6, R7=H, F, Cl, Br, (C1-C6) alkyl, (C1-C6) alkoxy, NH2, NHAlkyl, NAlkyl2; A=CH2CH2, CH=CHCH2, CH2CH2CH2, CH2CH[(C1-C6)alkyl]C(O), CH2CH2C(O)NHCH2CH2; CH2CH[(C1-C6)alkyl]C(O)N[(C1-C6)alkyl]CH2CH2, CH2CH(OH)CH2, CH2CH(OH)CH2NHCH2CH2, CH2CH(OH)CH2N[(C1-C6)alkyl]CH2CH2, CH2CHFCH2NHCH2CH2, CH2CHFCH2N[(C1-C6)alkyl]CH2CH2.
EFFECT: increased efficiency of the application of compounds.
6 cl, 1 dwg, 1 tbl, 38 ex
| Title |
Year |
Author |
Number |
| PHENOTHIAZINE-CONTAINING 1,2,3,4-TETRAHYDROPYRIDO[4,3-b]INDOLE DERIVATIVES AS AGENT FOR REDUCING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM, METHODS FOR PRODUCTION THEREOF, PHARMACOLOGICAL AGENT BASED THEREON AND METHOD OF REDUCING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM |
2013 |
- Bachurin Sergej Olegovich
- Sokolov Vladimir Borisovich
- Aksinenko Aleksej Jur'Evich
- Makhaeva Galina Fajvelevna
- Grigor'Ev Vladimir Viktorovich
- Ninkina Natal'Ja Nikolaevna
- Kukharskij Mikhail Sergeevich
|
RU2529899C1 |
| DERIVATIVES OF AZOLE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF ELICITING ACTIVITY WITH RESPECT TO SEROTONIN 5-HT- |
1995 |
- Dzheremi Dzhilmor
- Piter Taddeush Gallager
- Martin Viktor Majlz
- Vill'Jam Martin Outon
- Kolin Vill'Jam Smit
|
RU2146256C1 |
| ADAMANTANE-CONTAINING INDOLES AND THEIR HYDROCHLORIDES WITH MICROTUBULES STABILIZING PROPERTY, METHODS OF THEIR PRODUCTION, PHARMACOLOGICAL AGENT BASED THEREON AND METHOD OF TREATING AND PREVENTING DISEASES ASSOCIATED WITH MICROTUBULE SYSTEM DISORDERS |
2015 |
- Bachurin Sergej Olegovich
- Sokolov Vladimir Borisovich
- Aksinenko Aleksej Yurevich
- Epishina Tatyana Andreevna
- Goreva Tatyana Vladimirovna
- Shevtsova Elena Feofanovna
- Shevtsov Pavel Nikolaevich
|
RU2608631C1 |
| SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION BASED ON SAID, METHOD OF PATIENT TREATMENT, INTERMEDIATE COMPOUND |
1993 |
- Dzhen M.Brajt
- Uillard M.Uehlch
|
RU2130453C1 |
| SUBSTITUTED PYRIMIDINETHIOALKYL OR ALKYLESTER COMPOUNDS AND METHOD OF INHIBITION OF VIRAL REVERSE TRANSCRIPTASE ACTIVITY |
1996 |
- Richard A. N'Judzhent
- Donn G. Vishka
- Gari Dzh. Klik
- Dehvid R. Grejber
- Stiven Tomas Shljakhter
- Majkl Dzh. Merfi
- Dzhoel Morris
- Richard S. Tomas
|
RU2167155C2 |
| FLUORINE-CONTAINING SUBSTITUTED 5-[2-(PYRID-3-YL)-ETHYL]-2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-b]INDOLE HYDROCHLORIDES AS AGENTS DECREASING UNCONTROLLED PROTEIN AGGREGATION IN NERVOUS SYSTEM, BASED PHARMACEUTICAL PREPARATION AND METHOD OF USING IT |
2011 |
- Bachurin Sergej Olegovich
- Ustjugov Aleksej Anatol'Evich
- Ninkina Natal'Ja Nikolaevna
- Sokolov Vladimir Borisovich
- Aksinenko Aleksej Jur'Evich
- Shelkovnikova Tat'Jana Aleksandrovna
- Bolkunov Aleksej Viktorovich
|
RU2490268C2 |
| ANTIVIRAL REMEDIES FOR TREATMENT AND PREVENTION OF HIV INFECTION |
2021 |
- Kurkin Aleksandr Vitalevich
- Manasova Ekaterina Vladimirovna
- Kazyulkin Denis Nikolaevich
- Ivanov Vladimir Nikolaevich
- Shurygin Mikhail Gennadevich
|
RU2780103C1 |
| DERIVATIVES OF HYDROGENATED PYRIDO[4,3-B]INDOLES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT |
1995 |
- Zefirov N.S.
- Afanas'Ev A.Z.
- Afanas'Eva S.V.
- Bachurin S.O.
- Tkachenko S.E.
- Grigor'Ev V.V.
- Jurovskaja M.A.
|
RU2140417C1 |
| ANTIVIRAL REMEDIES FOR TREATMENT AND PREVENTION OF HIV INFECTION |
2020 |
- Kurkin Aleksandr Vitalevich
- Manasova Ekaterina Vladimirovna
- Kazyulkin Denis Nikolaevich
- Ivanov Vladimir Nikolaevich
- Shurygin Mikhail Gennadevich
|
RU2780101C2 |
| AMINOSUBSTITUTED PYRAZOLES AND INTERMEDIATE AMINO SUBSTITUTED PYRAZINES |
1993 |
|
RU2142455C1 |
