COMBINATIONS OF ANTI-CANCER MEDICINES Russian patent published in 2020 - IPC A61K39/395 A61K31/517 A61P35/00 

FIELD: medicine; oncology.

SUBSTANCE: group of inventions is intended for preventing or treating cancer. Combination for preventing or treating cancer involves 4-[(S)-2-azetidine-1-yl-1-(4-chloro-3-trifluoromethylphenyl)-ethylamino]-quinazoline-8-carboxylic acid amide or its physiologically acceptable salts and Her2 inhibitor, which is trastuzumab or lapatinib, or its physiologically acceptable salts. In addition, a pharmaceutical composition comprising said combination and adjuvants and/or adjuvants is provided. In another embodiment, a kit for preventing or treating cancer, consisting of separate packages (a) of an effective amount of 4-[(S)-2-azetidine-1-yl-1-(4-chloro-3-trifluoromethylphenyl)-ethylamino]-quinazoline-8-carboxylic acid amide or its physiologically acceptable salts, and (b) an effective amount of trastuzumab or lapatinib or its physiologically acceptable salts. Also disclosed is a method of preventing or treating cancer, comprising administering to a subject amide of 4-[(S)-2-azetidine-1-yl-1-(4-chloro-3-trifluoromethylphenyl)-ethylamino]-quinazoline-8-carboxylic acid or its physiologically acceptable salts and trastuzumab or lapatinib or its physiologically acceptable salts.

EFFECT: using the group of inventions enables providing more effective prevention or treatment of cancer by synergetic action of components of said combination.

8 cl, 2 dwg, 1 tbl, 10 ex