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2 734 346

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IPC

C07D493/14(2006-01-01)

A61K31/336(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2019114643, 2019-05-13

(24)

Start date

2019-05-13

(22)

Actual filing date

2019-05-13

(45)

Published

2020-10-15

(72)

Inventor

Dzhemilev Usein MemetovichDyakonov Vladimir AnatolevichKadikova Gulnara NazifovnaDzhemileva Lilya UseinovnaGazizullina Guzel Faritovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Ufimskij Federalnyj Issledovatelskij Tsentr Rossijskoj Akademii Nauk

METHOD FOR COMBINED PRODUCTION OF ANTI-3,9,12-TRIOXAPENTACYCLO [5.3.3.0.0.0]TRIDEC-5-ENE, SYN-3,9,12-TRIOXAPENTACYCLO [5.3.3.0.0.0]TRIDEC-5-ENE AND 3,6,10-TRIOXAPENTACYCLO [6.3.2.0.0.0]TRIDEC-12-ENE EXHIBITING ANTITUMOUR ACTIVITY Russian patent published in 2020 - IPC C07D493/14 A61K31/336 A61P35/00

Abstract RU 2734346 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing anti-3,9,12-trioxapentacyclo[5.3.3.0^2,4.0^8,10.0^11,13]tridec-5-ene of formula (1), syn-3,9,12-trioxapentacyclo[5.3.3.0^2,4.0^8,10.0^11,13]tridec-5-enes of formula (2) and 3,6,10-trioxapentacyclo[6.3.2.0^2,4.0^5,7.0^9,11]tridec-12-ene of formula (3), where R = Ph, Bu, Hex, (CH₂)₂OSOSCH_3, which consists in the fact that bicyclo[4.2.2]deca-2,4,7,9-tetraenes (BDT) react with m-chloroperoxybenzoic acid (m-PPBA), in molar ratio of RDD: m-CPBA = 2:(10–20), at 0–40 °C, in dichloromethane for 3–23 hours.

EFFECT: technical result is obtaining novel compounds which can be used in medicine as biologically active substances possessing antitumour activity.

4 cl, 2 tbl, 10 ex, 2 dwg

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RU 2 734 346 C1

Authors

Dzhemilev Usein Memetovich

Dyakonov Vladimir Anatolevich

Kadikova Gulnara Nazifovna

Dzhemileva Lilya Useinovna

Gazizullina Guzel Faritovna

Dates

2020-10-15—Published

2019-05-13—Filed