METHOD FOR SYNTHESIS OF BICYCLO[3,1,0]HEXANE DERIVATIVES AND INTERMEDIATE COMPOUND TO THIS END Russian patent published in 2010 - IPC C07C227/18 C07C229/50 C07C69/74 C07C61/06 C07D493/08 C07D303/04

Abstract RU 2388747 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to methods for synthesis of bicyclo[3.1.0]hexane derivatives, used as mGIuR agonists having formulae ,

, where R1 and R2 represent hydrogen, X is a halogen, R3 is -O-R^a , R^a is C_1-10alkyl, and R⁴ is (1) hydrogen or (2) Si-(R⁹)(R¹⁰)(R¹¹), where each of R⁹, R¹⁰ and R¹¹ is C_1-10alkyl, as well as intermediate compounds obtained when realising the said methods.

EFFECT: design of an efficient method for synthesis of bicyclo[3,1,0]hexane derivatives.

26 cl, 17 ex, 1 tbl

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RU 2 388 747 C2

Authors

Khartner Frederik U.

Tehn Lushi

Jasuda Nobuesi

Josikava Naoki

Dates

2010-05-10—Published

2004-11-03—Filed