METHOD OF PRODUCING 3,16,19-TRIOXAHEXACYCLO[10_5_3_0_0_0_0]ICOS-13-ENE EXHIBITING ANTITUMOUR ACTIVITY Russian patent published in 2020 - IPC C07D301/14 C07D303/06 A61K31/336 

Abstract RU 2726355 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a method of producing 3,16,19-trioxahexacyclo[10.5.3.02,4.02,11.015,17.018,20]icos-13-ene. Method involves interaction tricyclo[9.4.2.02,10]geptadeka-2,12,14,16-tetraene (C17H22) with m-chloroperoxybenzoic acid (m-CPBA) in molar ratio C17H22:m-CPBA=2:(10–20) at 0–40 °C in dichloromethane for 3–23 hours. Invention also relates to 3,16,19-trioxahexacyclo[10.5.3.02,4.02,11.015,17.018,20]icos-13-ene, exhibiting anti-tumor activity.

EFFECT: disclosed is a method of producing 3,16,19-trioxahexacyclo[10_5_3_02,4_02,11_015,17_018,20]icos-13-ene, exhibiting antitumour activity.

2 cl, 2 tbl, 2 ex

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RU 2 726 355 C1

Authors

Dzhemilev Usein Memetovich

Dyakonov Vladimir Anatolevich

Kadikova Gulnara Nazifovna

Dzhemileva Lilya Useinovna

Gazizullina Guzel Faritovna

Dates

2020-07-13Published

2019-02-18Filed