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2 735 664

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IPC

C07D493/20(2006-01-01)

A61K31/336(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2019112494, 2019-04-24

(24)

Start date

2019-04-24

(22)

Actual filing date

2019-04-24

(45)

Published

2020-11-05

(72)

Inventor

Dzhemilev Usein MemetovichDyakonov Vladimir AnatolevichKadikova Gulnara NazifovnaDzhemileva Lilya UseinovnaGazizullina Guzel Faritovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Ufimskij Federalnyj Issledovatelskij Tsentr Rossijskoj Akademii Nauk

METHOD FOR COMBINED PRODUCTION OF 3'-SUBSTITUTED SPIRO[3,9-DIOXATETRACYCLO[5_3_2_0_0]DODEC-5-ENE-11,2'-OXIRANES] AND SPIRO[3,9-DIOXATETRACYCLO[5_3_2_0_0]DODEC-5-EN-12,2'-OXIRANES] EXHIBITING ANTITUMOUR ACTIVITY Russian patent published in 2020 - IPC C07D493/20 A61K31/336 A61P35/00

Abstract RU 2735664 C2

FIELD: chemistry.

SUBSTANCE: invention relates to 3'-substituted spiro[3,9-dioxatetracyclo[5.3.2.0^2,4.0^8,10]dodec-5-en-11,2'-oxiranes] of formula (1) and spiro[3,9-dioxatetracyclo[5.3.2.0^2,4.0^8,10]dodec-5-en-12,2'-oxiranes of formula (2), where R = Ph, Hex. Invention also relates to a method for combined production of said compounds, which involves reacting bicyclo[4.2.2]deca-2,4,7-trienes with m-chloroperoxybenzoic acid at temperature of 0–40 °C, in dichloromethane for 3–23 hours

EFFECT: technical result is a method of producing novel compounds which can be used in medicine as biologically active substances having antitumour activity.

2 cl, 2 tbl, 3 ex, 1 dwg

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RU 2 735 664 C2

Authors

Dzhemilev Usein Memetovich

Dyakonov Vladimir Anatolevich

Kadikova Gulnara Nazifovna

Dzhemileva Lilya Useinovna

Gazizullina Guzel Faritovna

Dates

2020-11-05—Published

2019-04-24—Filed