ANILINE PYRIMIDINE DERIVATIVES AND USE THEREOF Russian patent published in 2020 - IPC C07D403/04 C07D413/04 A61K31/506 A61P35/00 

FIELD: organic chemistry.

SUBSTANCE: invention relates to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is selected from a group consisting of NR⁶ and O; R¹ and R² are independently selected from a group consisting of hydrogen, halogen, C_1-4 alkyl; R³ is C_1-4 alkoxy; R⁴ is selected from a group consisting of [2-(dimethylamino)ethyl](methyl)amino and (2-hydroxyethyl)(methyl)amino; R⁵ is selected from a group consisting of hydrogen and C_1-3 alkoxy C_1-3 alkyl; R⁶ is selected from a group consisting of hydrogen and C_1-4 alkyl. Invention also relates to a pharmaceutical composition based on a compound of formula (I) or a pharmaceutically acceptable salt thereof, a method of treating said diseases and using the compound of formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition based thereon.

EFFECT: obtaining novel heterocyclic compounds having the properties of EGFR inhibitor and double mutant EGFR-L858R/T790M, useful in treating malignant lung tumor, including non-small-cell lung cancer, small-cell lung cancer, lung adenocarcinoma and squamous cell lung cancer.

12 cl, 2 tbl, 15 ex