PYRROLOPYRIMIDINE COMPOUND Russian patent published in 2019 - IPC C07D487/04 A61K31/519 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel pyrrolopyrimidine compound of general formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof. In general formula (I)

each of R₁ and R₂ is independently selected from a group consisting of H, halogen, cyano, C_1-8alkyl, -NR₇R₈, -NH-C_1-6alkylene-NR₉R₁₀, -NHCO-C_1-6alkylene-NR₉R₁₀, -NH-C_1-6alkylene-CO-NR₉R₁₀, -NHCO-C_1-6alkylene-COO-C_1-6alkyl, -NH-C_3-6cycloalkylene-CO-NR₉R₁₀, -NH-C_2-6alkenylene-CONR₉R₁₀, -NH-C_1-6alkylene-cyano, -NHCO-NH-R₁₁, -CONR₁₂R₁₃ and -CONH-C_1-6alkylene-NR₁₂R₁₃, wherein C_1-8alkyl is optionally substituted with hydroxyl, halogen, -NH₂, -NH (C_1-6alkyl), -N (C_1-6alkyl)₂, provided that R₁ and R₂ simultaneously are not H; each of R₇ and R₈ is independently selected from a group consisting of H, C_1-6alkyl, C_1-6alkylcarbonyl and C_1-6alkylsulphonyl; or R₇ and R₈ together with atom N, to which they are bonded, form 5- or 6-member heterocyclyl, and said 5- or 6-member heterocyclyl contains atom N as a heteroatom and optionally substituted with oxo; each of R₉ and R₁₀ is independently selected from a group consisting of H, hydroxyl and C_1-6alkyl; or R₉ and R₁₀ together with atom N, to which they are bonded, form 5- or 6-member heterocyclyl with 1-2 heteroatoms selected from N and O; R₁₁ is selected from a group consisting of 5-member heteroaryl containing two N atoms and atom O as heteroatoms and optionally having substituent C_1-4alkyl; each of R₁₂ and R₁₃ is independently selected from a group consisting of H and C_1-6alkyl; R₃ is selected from a group consisting of H and halogen; R₄ is selected from a group consisting of cyano and -CONH₂; and each of R₅ and R₆ is independently selected from a group consisting of H, hydroxyl and halogen.

EFFECT: compounds can be used for treating a tumour caused by Janus kinase activity, such a disease can be lymphoma, leukaemia.

19 cl, 7 tbl, 34 ex