2-AMINOQUINAZOLINE DERIVATIVES AS P70S6 KINASE INHIBITORS Russian patent published in 2020 - IPC C07D471/04 C07D487/04 A61K31/519 A61P35/00 A61P25/28 

FIELD: organic chemistry.

SUBSTANCE: invention relates to a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein one of Y and Z is R³ and the other is Ar²; Q¹ is C_1-4 alkylene group, optionally containing one substitute selected from hydroxy, provided that, in the presence of a hydroxy substituent between the hydroxy substituent and the nitrogen atom to which Q² is bonded, there are at least two carbon atoms; Q² represents a bond or C_1-3 alkylene group; R¹ is selected from hydrogen, NR^xR^y and Cy¹ group; R^x and R^y are identical or different and each represents C_1-4 alkyl; Cy¹ is C-linked morpholine; all R², R³ and R⁴ are hydrogen; Ar¹ is a phenyl ring optionally containing 1 or 2 substituents R⁵, which are identical or different and are selected from a halogen and a group R^a-R^b; R^a is a bond, O or NR^cSO₂; R^b is selected from hydrogen, C_1-8 alkyl group; R^c is hydrogen; and Ar² is 5.6 a condensed heteroaromatic ring, containing 2, 3 or 4 nitrogen atoms as heteroatomic ring members, optionally containing 1 substituent R⁷, selected from C_1-4 alkyl and cyano. Invention also relates to specific derivatives of the compound of formula (1), a pharmaceutical composition based on the compound of formula (1), a method of treating said diseases and use of the compound of formula (1).

EFFECT: obtaining novel heterocyclic compounds having P70S6K inhibitor properties.

12 cl, 4 dwg, 44 ex