METHODS FOR SELECTIVE INTRODUCTION OF PROTECTIVE GROUPS INTO RESORCINOL DERIVATIVES Russian patent published in 2020 - IPC C07D213/80 C07D405/12 

FIELD: organic synthesis.

SUBSTANCE: invention relates to a method for selective introduction of a protective group into a compound of formula (I). Method involves reacting a compound of formula (I) with a compound of formula (II) in an inert aprotic solvent in the presence of a base to obtain a compound of formula (III). In formulas (I)–(III), R¹ and R² independently represent hydrogen or halogen; or R¹ and R² form together with bearing carbon atoms a pyrone cycle, which is substituted with R³ and R⁴, where R³ and R⁴ are independently selected from hydrogen, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₆-C₁₀ aryl C₁-C₆ alkyl, NHCOC₁-C₆ alkyl; or R³ and R⁴ are bonded together to form 5- or 6-member carbocyclic moiety, optionally containing one or more double bonds; Z is CO and Y is OH or -N₃.

EFFECT: disclosed method enables to selectively introduce a protective group into resorcinol derivatives and 5,7-dihydroxycoumarin in one simple step.

9 cl, 16 ex