CASPASE INHIBITORS AND USE THEREOF Russian patent published in 2009 - IPC C07D213/74 C07D213/75 C07D213/76 C07D213/81 C07D213/82 C07D405/12 C07D417/12 A61K31/4412 A61P19/02 A61P31/12 

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds with formula I: , in which: R¹ is R⁶C(O)-, HC(O)-, R⁶SO₂-, R⁶OC(O)-, (R⁶)₂NC(O)-, R⁶-, (R⁶)₂NC(O)C(O)-; R² is a hydrogen atom, -CF₃ or R⁸; R³ is a hydrogen atom or (C1-C4)aliphatic group-; R⁴ is -COOH; R⁵ is -CH₂F or -CH₂O-2,3,5,6- tetrafluorophenyl; R⁶ is (C1-C12)aliphatic or (C3-C10)cycloaliphatic group, (C6-C10)aryl-, (C3-C10)heterocyclyl-; and where R⁶ is substituted with up to 6 substitutes, independently chosen from R; R is a halogen atom, OR⁷ and -R⁷; R⁷ is (C1-C6)aliphatic group-, (C3-C10)cycloaliphatic group; R8 is (C1-C12)aliphatic- or (C3-C10)cycloaliphatic group; to a pharmaceutical composition with caspase-inhibiting activity, based on compound with formula I, to methods of treatment as well as to methods of inhibiting caspase-mediated functions and to a method of reducing production of IGIF or IFN-β. The invention also relates to a method of preserving cells, as well as to a method of producing compound with formula I.

EFFECT: new compounds are obtained and described, which can be used for treating diseases in the development of which caspase activity takes part.

34 cl, 4 tbl, 43 ex