FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes derivatives of arylsulfonylaminohydroxamic acid of the general formula (I) 
where values Ar, X, n, R3, R4 are given in p. 1 of the invention claim. Compounds are inhibitors of matrix metalloproteinases or tumor necrosis factor producing. Compounds can be used for treatment of patients with arthritis, cancer, tissue ulcers, septic shock. Invention describes the method of their synthesis, the method of inhibition, the method of patients treatment and the pharmaceutical composition based on compounds of the formula (I). EFFECT: improved method of synthesis, enhanced effectiveness of treatment. 18 cl, 1 tbl, 19 ex
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1996 |
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|
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