THERAPEUTIC, DIAGNOSTIC AND PROGNOSTIC METHODS FOR BLADDER CANCER Russian patent published in 2020 - IPC C12Q1/68 

FIELD: biotechnology.

SUBSTANCE: described is a method for diagnosing bladder cancer in a patient, involving the following steps: a) determining the expression level of at least one of the following genes: FGFR3, TP53 and EGFR, in the sample obtained from the patient; and b) comparing the expression level of at least one of said gene with a control level of at least one of said gene, wherein the increase in the expression level of at least one of said gene in the patient's sample relative to the reference level indicates that the patient suffers bladder cancer. What is also described is a method for predicting a patient suffering NMIDMP, including: a) determining the expression level of at least one of the following genes: FGFR3, TP53 and EGFR, in the sample obtained from the patient; b) comparing the expression level of at least one of said gene with a reference level of at least one of said gene, and c) determining a patient's prediction, wherein an unfavorable prognosis is noted, if the level of expression of at least one above gene in the patient's sample is increased relative to the reference level. Also disclosed is a method of predicting a patient suffering bladder cancer, involving: a) determining the expression level of at least one of the following genes: FGFR3, TP53 and EGFR, in the sample obtained from the patient; b) comparing the expression level of at least one of said gene with a control level of at least one of said gene; and c) determining a patient's prediction, wherein the unfavorable prognosis is observed if the level of expression of at least one above gene in the patient's sample is increased relative to the control level.

EFFECT: invention can be used for diagnosing and predicting the clinical course of bladder cancer.

89 cl, 18 dwg, 4 tbl, 6 ex