FIELD: biotechnology.
SUBSTANCE: described is a group of inventions comprising a single-chain ribonucleic acid for inhibiting expression of a target gene, containing region X and region Y, a composition for inhibiting expression of a target gene containing said single-chain ribonucleic acid, a pharmaceutical composition, a method for inhibiting expression of a target gene, a method of treating a disease selected from a malignant growth, pulmonary fibrosis or hepatic fibrosis and use of single-chain ribonucleic acid for treating said diseases. In one embodiment, the X domain of single-chain ribonucleic acid comprises (a) a sequence of a "guide" chain or (b) a sequence of a "passenger" chain of mature siRNA and 3'-end of said region X and 5'-end of region Y are linked through a linker region having a non-nucleotide structure.
EFFECT: invention extends the range of agents for inhibiting expression of a target gene.
33 cl, 3 tbl, 11 ex, 13 dwg
| Title |
Year |
Author |
Number |
| PHARMACEUTICAL COMPOSITIONS, KITS AND METHODS OF TREATING TUMORS |
2019 |
- Chen, Syaotsin
- Chzhou, Syujsha
- Rojzman, Bernard
- Chzhou, Grejs Goin
|
RU2810906C2 |
| COMPOSITION FOR REDUCING HAIR GRAYING, STIMULATING HAIR GROWTH AND/OR PREVENTING OR REDUCING HAIR LOSS, CONTAINING DOUBLE-STRANDED MCRNA AS ACTIVE INGREDIENT |
2022 |
- Park, Han-Oh
- Lee, Sang-Kyu
- Kwon, Oh Seung
- Goh, Eun-Ah
|
RU2823325C1 |
| NUCLEIC ACIDS FOR INHIBITING EXPRESSION OF LPA IN CELL |
2018 |
- Dames Sibylle
- Schubert Steffen
- Tenbaum Stephan
- Frauendorf Christian
- Bethge Lucas
- Hauptmann Judith
- Weingartner Adrien
- Rider David Anthony
|
RU2822093C1 |
| AMPHIREGULIN GENE-SPECIFIC DOUBLE-STRANDED OLIGONUCLEOTIDES AND COMPOSITIONS CONTAINING THEM FOR THE PREVENTION AND TREATMENT OF FIBROSIS-RELATED DISEASES AND RESPIRATORY DISEASES |
2019 |
- Kim, Tae-Rim
- Yoon, Pyoung Oh
- Ko, Youngho
- Bae, Seon Joo
- Park, Han-Oh
- Son, Seung Seob
- Jun-Hong, Park
- Yun, Sung Il
|
RU2795179C2 |
| MIRNA STRUCTURES WITH HIGH ACTIVITY AND REDUCED EXPOSURE OUTSIDE THE TARGET |
2016 |
- Ying, Wenbin
- Minomi, Kenjirou
- Harborth, Jens
- Cina, Cima
- Zheng, Jane
- Vaish, Narendra
|
RU2788030C2 |
| NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, METHOD OF PRODUCTION AND USE |
2020 |
- Chzhan, Khunyan
- Gao, Shan
- Kan, Dajvu
- Tyan, Baolej
|
RU2819689C2 |
| SILENSING OF TGF-BETA 1 AND Cox-2 USING siRNA DELIVERED IN A POLYPEPTIDE NANOPARTICLE, SINGLE AND IN COMBINATION WITH IMMUNE CHECKPOINT INHIBITORS FOR THE TREATMENT OF MALIGNANT NEOPLASM |
2019 |
- Evans, David M.
- Lu, Patrick Y.
|
RU2797510C2 |
| NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND CONJUGATE, METHOD OF PRODUCTION AND USE |
2020 |
- Chzhan, Khunyan
- Gao, Shan
- Kan, Dajvu
|
RU2816898C2 |
| COMPOSITIONS AND METHODS FOR INHIBITION OF PROTEOLYTIC PATH OF ARGININE/N-DEGRON |
2020 |
- Lebof Dominik
- Prikazchikova Tatyana Aleksandrovna
- Abakumova Tatyana Olegovna
- Anderson Deniel Griffit
- Zatsepin Timofej Sergeevich
- Pyatkov Konstantin Ivanovich
- Rim Lyuk Khyunsik
|
RU2787841C2 |
| COMPOSITION FOR PREVENTION OR TREATMENT OF DISEASE ASSOCIATED WITH OBESITY, CONTAINING AMPHIREGULIN-SPECIFIC DOUBLE-CHAIN OLIGONUCLEOTIDE STRUCTURE |
2021 |
- Park, Jun Hong
- Park, Han-Oh
- Yun, Sung Il
- Kim, Tae Rim
- Hwang, Soo Hyun
- Song, Kang
- Jung, Sang Hyuk
- Kim, Jangseon
- Lee, Mi Sun
- Choi, Soonja
- Son, Seung-Seob
|
RU2810514C1 |
