FIELD: biotechnology.
SUBSTANCE: method for detection of protein of a folate receptor 1 (hereinafter – FOLR1) in a cancer sample is proposed. The cancer sample is obtained from a patient, which has been treated with an active agent containing an antibody or its antigen-binding fragment, which bind to FOLR1. The method includes contact of the specified sample with a detecting antibody to FOLR1.
EFFECT: invention can be used in the diagnostics of cancer, for example, for stratification of patients.
17 cl, 15 dwg, 6 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHODS FOR DETECTING FOLATE RECEPTOR 1 IN PATIENT SAMPLE | 2018 |
|
RU2759410C2 |
| ANTIBODIES AGAINST FOLIC ACID RECEPTOR 1, THEIR IMMUNOCONJUGATES AND USE | 2011 |
|
RU2740479C2 |
| COMBINATION THERAPY BASED ON T-CELL-ACTIVATING BISPECIFIC ANTIGEN-BINDING MOLECULES AGAINST CD3 AND FOLATE RECEPTOR 1 (FOLR1) AND ANTAGONISTS BINDING TO PD-1 AXIS | 2015 |
|
RU2753902C2 |
| ANTIBODIES AND ANALYSIS METHODS FOR FOLIC ACID 1 RECEPTOR DETECTION | 2014 |
|
RU2725825C2 |
| IMPROVED ANTIGEN-BINDING RECEPTORS | 2018 |
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RU2807742C1 |
| IMMUNOGLOBULIN WITH TANDEM FAB- FRAGMENTS AND ITS APPLICATION OPTIONS | 2017 |
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| BISPECIFIC ANTIBODIES BINDING TO TFR | 2019 |
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| ANTIBODIES CONTAINING POLYPEPTIDE INTEGRATED INTO FRAME REGION 3 | 2019 |
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