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(19)

(11)

2 740 648

(13)

(51)

IPC

C07K14/725(2006-01-01)

A61K38/17(2006-01-01)

A61K35/17(2015-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2016124179, 2014-11-21

(24)

Start date

2014-11-21

(22)

Actual filing date

2014-11-21

(45)

Published

2021-01-19

(72)

Inventor

Smith, Sheena N.Harris, Daniel T.Kranz, David M.Schmitt, Thomas M.Greenberg, Philip D.

(73)

Holder

The Board Of Trustees Of The University Of IllinoisFred Hutchinson Cancer Research Center

CONSTRUCTED HIGH-AFFINITY HUMAN T-CELL RECEPTORS Russian patent published in 2021 - IPC C07K14/725 A61K38/17 A61K35/17 A61P35/00

Abstract RU 2740648 C2

FIELD: immunology.

SUBSTANCE: disclosed is a modified T-cell receptor which binds to a complex of peptide WT1 and molecules HLA-A2, and its antigen-binding fragment. Compositions are also described and used in preparing a drug for treating a subject having cancer.

EFFECT: this group of inventions can find application in therapy of WT1 related diseases.

10 cl, 12 dwg, 3 tbl, 12 ex

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RU 2 740 648 C2

Authors

Smith, Sheena N.

Harris, Daniel T.

Kranz, David M.

Schmitt, Thomas M.

Greenberg, Philip D.

Dates

2021-01-19—Published

2014-11-21—Filed