FIELD: biotechnology.
SUBSTANCE: humanized anti-HLA-A2 antibodies are proposed. CAR are also proposed, which include humanized anti-HLA-A2 antibodies. Modified cells including CAR, and methods for use of such modified cells for stimulation of immune tolerance in a subject are also proposed.
EFFECT: invention provides obtaining CAR with reduced cross reactivity to several allelic variants of HLA-A.
18 cl, 13 dwg, 9 tbl
| Title | Year | Author | Number |
|---|---|---|---|
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