FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a chimeric molecule of antibody-T-cell receptor (TCR) (abTCR), specifically binding to a target antigen, as well as to a composition and a complex containing it. An effector cell representing the specified molecule on its surface, as well as an effector cell containing nucleic acid encoding the above-mentioned chimeric molecule are also presented. The invention also relates to a method for destroying a target cell representing an antigen target using the specified chimeric molecule.
EFFECT: invention is effective for the treatment of a disease associated with an antigen target in a person who needs it.
47 cl, 46 dwg, 8 tbl, 10 ex
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