FIELD: immunology.
SUBSTANCE: disclosed is a modified T-cell receptor (TCR) and an antigen-binding fragment thereof capable of binding survivin. Also disclosed are compositions targeted on cancer cells, and a method of treating a subject having cancer.
EFFECT: this group of inventions can find further application in cancer therapy.
11 cl, 5 tbl, 9 ex, 9 dwg
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Authors
Dates
2020-08-06—Published
2014-11-21—Filed