TREATMENT OF LIVER, BILE DUCT AND PANCREATIC DISORDERS Russian patent published in 2021 - IPC A61K38/04 A61K38/17 A61K38/26 A61P1/16 A61P1/18 A61P3/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to methods of treating or preventing disorders of the liver, bile ducts and pancreas. A method of treating or preventing a liver disease or disorder selected from a group consisting of toxic liver damage, alcoholic or non-alcoholic fatty liver disease (NAFLD), hepatic cirrhosis, hepatic insufficiency, hepatic fibrosis, liver sclerosis, hepatic encephalopathy, non-alcoholic steatohepatitis (NASH), wherein said method comprises administering an effective amount of α-defensin and/or β-defensin of mammals selected from a group consisting of hBD-2 (SEQ ID NO: 5), truncated hBD2 (SEQ ID NO: 17), hBD-1 (SEQ ID NO: 4), hBD-3 (SEQ ID NO: 6), and hBD-4 (SEQ ID NO: 7), β-defensin, which differs from hBD1, hBD2, hBD3, hBD4, or truncated hBD2 (SEQ ID NO: 17) by less than 5 conserved amino acid substitutions, HD5 (SEQ ID NO: 8), and/or HD6 (SEQ ID NO: 9), a subject in need thereof. Also disclosed are a method of treating or preventing a biliary disease or disorder, a method of treating or preventing a disease or a pancreatic disorder, method of treating or preventing a metabolic disease or disorder, using α-defensin and/or β-defensin in mammals in a method of treating and preparing a medicinal agent.

EFFECT: treatment of liver, bile duct and pancreatic disorders is offered.

35 cl, 38 dwg, 10 ex