FIELD: biotechnology.
SUBSTANCE: invention relates to therapeutic application of an arginine-depleting agent and can be used in medicine for treating at least one disease or pathological condition in which depletion of arginine stores leads to a therapeutic effect. Disclosed is the use of an arginine-depleting agent which is an arginine catabolising enzyme selected from arginase protein, arginine deiminase or arginine decarboxylase.
EFFECT: invention provides an effective treatment of obesity, as well as a metabolic disorder selected from glucose intolerance, hyperglycemia, diabetes mellitus, hepatic steatosis, renal steatosis, pancreatic steatosis, cardiac steatosis and insulin resistance, and a related complication, which is one or more pathological conditions selected from diabetic nephropathy, diabetic vasculopathy, diabetic neuropathy, hypercholesterolemia, dyslipidemia, hypertriglyceridemia, hyperleptinemia, hyperinsulinemia, steatosis, steatohepatitis, hypertension, cardiovascular disease and brown fat whitening.
13 cl, 70 dwg, 19 tbl, 43 ex
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