FIELD: biotechnology.
SUBSTANCE: invention relates to therapeutic proteins fused with an Fc fragment, and can be used in medicine for the treatment of obesity, hyperlipidemia, non-alcoholic fatty liver disease, diabetes or diabetic cardiomyopathy. A combined therapeutic agent consisting of the first pharmaceutical composition containing the FGF21 Fc fusion protein and the second pharmaceutical composition containing the GLP-1 Fc fusion protein, and its use for the prevention or treatment of obesity, hyperlipidemia, non-alcoholic fatty liver disease, diabetes or diabetic cardiomyopathy are proposed.
EFFECT: achievement of a synergistic effect upon combined administration of the FGF21 Fc fusion protein and the GLP-1 Fc fusion protein in animal models of obesity, diabetes, hyperlipidemia, non-alcoholic fatty liver disease, diabetic cardiomyopathy.
7 cl, 9 dwg, 4 tbl, 3 ex
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