METHOD OF PRODUCING BIOCOMPATIBLE POROUS ZIRCONIUM DIOXIDE CERAMICS FOR ENDOPROSTHESIS REPLACEMENT Russian patent published in 2021 - IPC C04B35/488 C04B35/626 C04B38/06 B82Y40/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, more specifically to the technology of producing biocompatible composite materials which can be used for making bone implants in restorative surgery. Liquid-phase directed synthesis of precursor powders in ZrO₂-Y₂O₃-Al₂O₃ system is carried out by selecting as initial reagents salts ZrO(NO₃)₂⋅2H₂O, Y(NO₃)₃⋅5H₂O and Al(NO₃)₃⋅9H₂O, from which diluted solutions are prepared and two-stage precipitation of hydroxides from corresponding salts is carried out with aqueous solution of ammonia NH₄OH until complete precipitation of all hydroxides, mixing and obtaining sediment with high degree of homogeneity. Gel-like precipitate is filtered and subjected to rapid freezing at -25°C for 24 hours, after which the synthesized powder composition [(ZrO₂)_0.97(Y₂O₃)_0.03]_0.8(Al₂O₃)_0.2 dried and thermally treated at 800°C. Synthesized powder is added with optimum composition of pore-forming additive with content of 10 wt% of calcium hydroxyapatite Ca₁₀(PO₄)₆(OH)₂ and 30 wt.% (NH₄)₂CO₃, after which obtained nanopowder mixtures are formed into compacts by cold uniaxial pressing at pressure of 100 MPa and sintered in air at 1300°C with isothermal holding for 2 hours and heating rate of 350-400°/h.

EFFECT: disclosed method provides synthesis and production of composition based on nanopowders [(ZrO₂)_0.97(Y₂O₃)_0.03]_0.8(Al₂O₃)_0.2 highly porous strong ceramics for medical purposes for replacement surgery and transplantology.

1 cl, 1 tbl, 4 dwg