FIELD: biotechnology.
SUBSTANCE: neutralizing antibodies to a type I receptor of human pituitary adenylate cyclase-activating polypeptide (hereinafter – PAC1), as well as pharmaceutical compositions containing such antibodies are proposed. Polynucleotides, expression vectors, and host cells for the production of antibodies are also proposed. In addition, methods for the treatment or prevention of conditions related to headache, such as migraine and cluster headache, using the specified neutralizing antibodies, are described.
EFFECT: invention provides increased inhibitory activity against human PAC1.
44 cl, 20 dwg, 24 tbl, 7 ex
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