BOTULINUM TOXIN CONTAINING COMPOSITION Russian patent published in 2021 - IPC A61K38/48 A61K47/36 A61Q19/08 A61Q19/00 A61K38/16 A61K31/728 

FIELD: pharmaceuticals.

SUBSTANCE: present invention refers to a composition containing (a) botulinum toxin and (b) non-crosslinked hyaluronic acid, and its application for treating or preventing dystonia, spastic condition and/or wrinkles. Besides, the present invention refers to a method for cosmetic smoothing or wrinkle prevention, which involves the stage of introduction of the present composition. Described is a composition for preventing or treating a disease or condition which can be prevented or cured by botulinum neurotoxin A, comprising a) 2–4 or 20–40 units of botulinum neurotoxin A per milligram of non-crosslinked hyaluronic acid, b) 2.5–9 mg of non-crosslinked hyaluronic acid having average molecular weight from 2.5 to 4.5 MDA, where the disease or condition is selected from focal, segmental or generalized dystonia, spastic condition or wrinkles, and where the polydispersity index of the non-crosslinked hyaluronic acid ranges from 1.1 to 4.0.

EFFECT: technical result is creation of improved composition with botulinum neurotoxin, providing prolonged action of botulinum toxin, prevention or at least considerable reduction of undesirable by-effects.

12 cl, 1 ex, 2 dwg