BENZOXAZINE-OXAZOLIDINONE COMPOUND DISPLACED BY A NITROGEN-CONTAINING HETEROCYCLE, METHOD OF SYNTHESIS AND APPLICATION THEREOF Russian patent published in 2021 - IPC C07D498/04 C07D498/06 C07D513/08 C07D519/00 A61K31/5383 A61K31/541 A61P31/06 

FIELD: organic chemistry.

SUBSTANCE: invention relates to organic chemistry, namely to a compound of formula (I) or to isomers thereof, where X₁ and X₂ each constitute ; R₁ constitutes -NHR₃, -NHCOR₃, -NHSO₂R₃, -NHCOOR₃, non-substituted 5-membered heteroaryl, wherein the non-substituted 5-membered heteroaryl in R₁ contains three N atoms; R₃ is independently selected from an atom of hydrogen, substituted or non-substituted C₁-C₄ alkyl, non-substituted 3-6-membered cycloalkyl, non-substituted 4-membered heterocyclyc group, non-substituted 5-6-membered heteroaryl; wherein said non-substituted 4-membered heterocyclyc group and said non-substituted 5-6-membered heteroaryl in R₃ contain between one and three heteroatoms selected from N or O; the substituents in R₃ are each independently selected from F, C₁-C₃ alkyle; R₂ constitutes a non-substituted , non-substituted , non-substituted ; Y₁ constitutes -S-, -S(=O)-, -S(O₂)-, -C(F₂)-; Y₂ constitutes -O-; a, b, c, d, e and f each equals 1. The invention also relates to a method of synthesis of a compound of the formula (I), a pharmaceutical composition based on the compound of the formula (I) and application thereof.

EFFECT: technical result: new heterocyclic compounds are synthesized, said compounds useful in treatment and/or prevention of the microbial infection induced by Mycobacterium tuberculosis.

13 cl, 4 tbl, 39 ex