FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to a library of vectors containing human HC-CDR3 regions of various lengths, where the diversity of this library is focused by the HC-CDR3 region.
EFFECT: resulting library is optimized in such a way that redundancy is reduced for short HC-CDR3 loops, and the overlap of HC-CDR3 region variants for large loop lengths is increased, which allows the resulting library to be used for effective selection of recombinant antibodies against target antigens.
10 cl, 5 tbl, 11 ex, 15 dwg
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