ANTIBODIES TO TICAGRELOR AND APPLICATION METHODS Russian patent published in 2021 - IPC C07K16/44 C07D487/04 A61K39/395 A61P7/04 

FIELD: immunology.

SUBSTANCE: group of inventions relates to the field of immunology, in particular to antibodies that specifically bind to ticagrelor or the active metabolite of ticagrelor. An antibody or its antigen-binding fragment is proposed that specifically bind to ticagrelor or its active metabolite with IC₅₀ of about 100 nM or lower and neutralize its antiplatelet effect. A nucleic acid molecule encoding the specified antibody or its antigen-binding fragment, an expression vector containing the specified nucleic acid, a host cell for obtaining the above-mentioned antibody or its antigen-binding fragment containing a vector are also proposed. The antibody inhibits the action or binding of ticagrelor or its active metabolite to the P2Y₁₂ receptor, and also provides activation of ADP-induced platelet aggregation in the patient.

EFFECT: antibodies are applicable in therapeutic methods for neutralizing the activity of inhibitors of platelet activation, aggregation and granulation, activators of platelet disaggregation and antithrombotic agents, for example, in methods for treating or preventing acute bleeding in a patient who was injected with ticagrelor, or in a patient who underwent surgery and who was injected with ticagrelor.

29 cl, 12 dwg, 9 tbl, 14 ex