ORAL ADMINISTRATION OF UNSTABLE OR POORLY ABSORBED DRUGS Russian patent published in 2021 - IPC A61K9/107 A61K47/02 A61K47/14 A61K38/28 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, namely to an oral dosage form for rapid reduction of blood glucose, which contains: an antacid sufficient to increase the gastric pH of a mammal, at least up to about 3 after taking the dosage form, and a combination of a therapeutically effective amount of drug for rapid blood glucose reduction and one or more non-ionic surfactants as a self-microemulsifying drug delivery system (SMEDDS) that induced spontaneous emulsification upon contact between the combination and an aqueous medium under soft mechanical stirring conditions, also relates to a set for oral administration of a drug to reduce blood glucose, also relates to a method for oral administration of a drug to reduce blood glucose, which involves combining a therapeutically effective amount of a drug and one or more non-ionic surfactants into a combination as a self-microemulsifying drug delivery system (SMEDDS) so that the combination is spontaneously emulsified upon contact with an aqueous medium under light mechanical stirring conditions; mixing a combination, an aqueous medium, and an antacid sufficient to raise the mammalian gastric pH to at least 3 to produce an emulsified mixture; and then orally administer the emulsified mixture to the mammal, also relates to the method of oral administration of a drug to reduce blood glucose, which involves combining a therapeutically effective amount of a drug and one or more non-ionic surfactants, in combination as a self-microemulsifying drug delivery system (SMEDDS) so that the combination is spontaneously emulsified upon contact with an aqueous medium under light mechanical stirring conditions; oral administration to a mammal of an antacid sufficient to raise the mammalian gastric pH to at least 3; and oral administration of the combination to the mammal is close enough in time to administration of the antacid, so that the gastric pH of the mammal remains at least 3 while the combination is being administered.

EFFECT: group of inventions provides development of fast-acting and short-acting medical compositions.

44 cl, 15 dwg, 7 ex