FIELD: pharmaceutical industry.
SUBSTANCE: group of inventions relates to a pharmaceutical combination for the prevention or treatment of diabetes or at least one of the metabolic diseases associated with it; to its use for the specified purpose; to its use for the preparation of a pharmaceutical product; to a method of preventing or treating diabetes or at least one of the metabolic diseases associated therewith by administering a therapeutically effective amount of the combination. The proposed pharmaceutical combination contains a therapeutically effective amount of a compound of formula 1, its pharmaceutically acceptable salts, hydrates, solvates or mixtures thereof and a therapeutically effective amount of at least one of evogliptin, sitagliptin, elafibranor, dapagliflozin, metformin and voglibose, wherein formula 1 is
, where A is an oxadiazole group substituted with a straight or branched C1-C6 alkyl group; B is a pyrimidine group substituted with a linear or branched C1-C6 alkyl group; X each is F.
EFFECT: group of inventions provides a synergistic effect in the prevention or treatment of diabetes and related metabolic diseases.
8 cl, 10 dwg, 5 ex
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| HETEROCYCLIC SUBSTANCES-GPR119 AGONISTS | 2017 |
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| THIAZOLOPYRIDINE DERIVATIVES AS GPR119 AGONISTS | 2017 |
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| SUBSTITUTED 4-{[4-(3,3-DIOXIDO-1,3-BENZOXATHIOL-6-YL)ARYLOXY]METHYL}PIPERIDINES AS GPR119 RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR PRODUCING AND USING THEM | 2014 |
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