METHOD FOR DETECTING ANTIBODIES - CLASS G IMMUNOGLOBULINS IN BLOOD SERUM TO PATHOGENS OF SEVERE ACUTE RESPIRATORY VIRAL INFECTIONS, INCLUDING SARS-COV-2, WITH SIMULTANEOUS PROGNOSIS OF COVID-19 SEVERITY, BASED ON HYDROGEL BIOCHIP Russian patent published in 2021 - IPC G01N33/543 G01N33/533 G01N33/549 C12Q1/70 

FIELD: virology/immunology.

SUBSTANCE: invention relates to the field of virology and immunology. A method is proposed for multiplex detection of class G antibodies against antigens of the SARS-CoV-2 coronavirus and other viruses of the beta-coronavirus family, influenza A and B viruses, parainfluenza viruses of types II and III, while simultaneously detecting prognostic class G autoantibodies against type I interferons associated with severe course of coronavirus infection COVID-19. The method includes providing a biochip with immobilized viral proteins and markers of the severity of coronavirus infection, interaction of a blood serum sample with a biochip with the formation of specific binary immune complexes of proteins with antibodies in the blood serum sample, detection of formed immune complexes, registration and interpretation of analysis results on a biochip.

EFFECT: invention provides for the simultaneous differentiation of coronavirus infection from influenza and other acute respiratory viral infections and the identification of carriers of autoantibodies to markers of the severity of coronavirus infection among patients infected with COVID-19.

7 cl, 1 tbl, 5 dwg, 3 ex