PEPTIDE IMMUNOGENS AND VACCINE COMPOSITION AGAINST COVID-19 WITH THE USE OF PEPTIDE IMMUNOGENS Russian patent published in 2021 - IPC C07K14/00 A61K39/215 A61P31/14 C07K16/10 

Abstract RU 2743593 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology. Disclosed are the following peptide immunogens: the first peptide immunogen used as a component of vaccine composition against COVID-19 characterized by the amino acid sequence CRLFRKSNLKPFERDISTEIYQAGS (SEQ ID NO: 1); the second peptide immunogen used as a component of vaccine composition against COVID-19 characterized by the amino acid sequence CKEIDRLNEVAKNLNESLIDLQELGKYEQYIK (SEQ ID NO: 2). Disclosed is vaccine composition against COVID-19 characterized by the fact that it contains peptide immunogens having amino acid sequences (SEQ ID NO: 1) and (SEQ ID NO: 2). These peptide immunogens are covalently linked in the form of conjugates with a carrier protein, which is a chimeric recombinant protein MBP-6xHis-N_nCoV-2019 including the N protein of the SARS Cov-2 coronavirus characterized by the amino acid sequence (SEQ ID NO: 3). The mixture of the above conjugates of peptide immunogens and a carrier protein is sorbed onto a pharmaceutically acceptable adjuvant.

EFFECT: peptide immunogens and vaccine compositions that carry minimum necessary antigenic determinants for the formation of a specific immune response in rabbits, weasels and hamsters and induce protective immunity against COVID-19.

5 cl, 4 tbl, 7 ex, 5 dwg

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RU 2 743 593 C1

Authors

Ryzhikov Aleksandr Borisovich

Ryzhikov Evgenij Aleksandrovich

Bogryantseva Marina Polikarpovna

Gavrilova Elena Vasilevna

Danilenko Elena Dmitrievna

Imatdinov Ilnaz Ramisovich

Maksyutov Rinat Amirovich

Nechaeva Elena Avgustovna

Popova Anna Yurevna

Pyankov Oleg Viktorovich

Pyankova Olga Grigorevna

Susloparov Ivan Mikhajlovich

Dates

2021-02-20Published

2020-12-09Filed